A new method in bioprinting has been developed by an Oxford University spin-off company, OxSyBio, that will enable researchers to print and arrange cells in pre-determined 3D architectures. This novel method leverages the use of a lipid coating which encapsulates cells within protective nanolitre droplets during the printing process. Dr Alexander Graham, the lead author and scientist of OxSynBio, demonstrated the application of this technique with human embryonic kidney (HEK) cells and ovine mesenchymal stem cells (oMSCs). He was able to achieve high-resolution 3D geometries in the range of less than 200 microns while maintaining high cell viability. Learn more about this exciting work at their Nature publication – Scientific Reports.
In the most recent development, a clay-based bioink was developed and shown to provide improved drug delivery properties. A team of researchers from University of Southhampton and the Technische Universitat Dresden in Germany used a synthetic nanosilicate clay called Laponite to create a 3D printable bioink that supports mesenchymal stem cell growth. The material is combined with alginate and methylcellulose produces properties that make it suitable for bioprinting and drug delivery applications. To learn more about this innovative bioink, check out their most recent publication in Biofabrication.
Researchers at the University of Gothenberg in Sweden reported successful bioprinting with induced pluripotent stem cells (iPSCs) in a nanocellulose-alginate bioink to create cartilage in vitro. The experiments involved a comparison study between the use of alginate versus hyaluronic acid and their findings showed superior results in the alginate-based bioink for creating cartilage tissue structures. Get more detailed specifics about their research in this Nature Scientific Reports publication.